在口腔癌发生发展的影响因素中,染色体不稳定表现扮]了十分重要的角色。其中包括染色体数目异常和染色体结构改变。前者由于有丝分裂检查点缺陷和中心体异常,导致不正常的染色体分离。染色体结构改变与DNA损伤检查点和DNA双链断裂点修复系统缺陷有关,引起染色体易位或断裂发生。相关研究已证明,染色体不稳定发生的分子遗传学异常改变与口腔癌的发生发展密切相关。 Chromosome instability plays a very important role in the development of oral cancer. These include anomalies in the number of chromosomes and changes in chromosomal structure. The former due to mitotic checkpoint defects and centrosome abnormalities, leading to abnormal chromosome segregation. Chromosomal structural changes associated with DNA damage checkpoints and DNA double-strand breakpoint repair system defects that cause chromosomal translocations or breaks occur. Related studies have shown that chromosomal instability occurs in molecular genetic abnormalities and oral cancer is closely related to the occurrence and development.