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目的探讨幽门螺杆菌感染与胃息肉的相关性。方法用蛋白芯片技术检测296例患者血清中细胞毒素相关蛋白(CagA)、尿素酶(Ure)和空泡细胞毒素(VacA)3种抗体,14C呼气试验,同时行胃镜下快速尿素酶及组织病理检查。结果胃炎性息肉、胃增生性息肉、胃底腺息肉的患者幽门螺杆菌感染表达率分别为80.77%、75.00%和16.67%,胃底腺息肉幽门螺杆菌感染率明显低,分别与胃炎性息肉和胃增生性息肉组比较,差异有统计学意义(P<0.05)。结论幽门螺杆菌感染与胃的炎性息肉、增生性息肉发生有关,而与胃底腺息肉可能无关。
Objective To investigate the correlation between helicobacter pylori infection and gastric polyps. Methods The serum levels of CagA, Ure and VacA in 296 patients were detected by protein microarray. The 14C breath test was performed. In addition, the rapid urease and tissue under endoscopy Pathological examination. Results The rates of H.pylori infection in patients with gastritis polyposis, gastric hyperplastic polyps and gastric fundus polyps were 80.77%, 75.00% and 16.67%, respectively. The infection rate of Helicobacter pylori in gastric polyp was significantly lower than that in gastric polyps And gastric hyperplastic polyps group, the difference was statistically significant (P <0.05). Conclusion Helicobacter pylori infection is related to the inflammatory polyps and hyperplastic polyps in the stomach, but not to the polyps in the gastric fundus.