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本文概要的报告了麦迪霉素的药理研究。在急性毒性实验中,小鼠口服麦迪霉素的半数致死量(LD_(50))为5900±400mg/kg,腹腔注射的半数致死量为275±7mg/kg。在用狗所做的亚急性毒性实验中证明麦迪霉素的毒性较小。给家兔一次口服200mg/Kg,血浓度在30分钟达到高峰,约为7.54微克/毫升。24小时由尿中排出率为1.99％。给大鼠一次口服 200mg/kg,组织中的浓度以肝组织最高,其次为脾、肾、肺和胰,在脑组织中未能测出。
This article summarizes the pharmacological studies of mootinomycin. In the acute toxicity test, mice were given a median lethal dose (LD_ (50)) of 5,900 ± 400 mg / kg and a median lethal dose of 275 ± 7 mg / kg for intraperitoneal injections. Subacute toxicity experiments conducted with dogs demonstrated less toxicity of midecamycin. To rabbits once oral 200mg / Kg, the blood concentration peaked in 30 minutes, about 7.54 micrograms / ml. 24 hours by the urine discharge rate of 1.99%. To rats once orally 200mg / kg, the highest concentration of tissue in the liver, followed by the spleen, kidney, lung and pancreas, failed to detect in brain tissue.