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目的观察甲氨蝶呤联合米非司酮治疗异位妊娠的临床效果。方法选择2012年11月—2014年11月收治的异位妊娠患者82例,随机分为对照组和观察组各41例。对照组肌内注射甲氨蝶呤50 mg/m2,2次/d,连用3 d。观察组在对照组的基础上,口服米非司酮50 mg/次,2次/d,连用3 d。观察比较两组疗效、妊娠病灶包块大小、孕酮和β-HCG水平。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果对照组总有效率为70.7%,观察组为92.7%,两组比较差异有统计学意义(χ2=6.609,P<0.05)。治疗后,对照组妊娠病灶包块大小、孕酮和β-HCG水平分别为(2.13±0.28)cm、(25.29±3.76)ng/ml、(894.13±46.10)U/L,观察组分别为(0.95±0.17)cm、(3.34±1.12)ng/ml、(316.95±21.09)U/L,两组比较差异均有统计学意义(t=23.066、35.824、72.902,均P<0.05)。结论甲氨蝶呤联合米非司酮治疗异位妊娠效果好,可明显缩小妊娠病灶包块大小,降低孕酮和β-HCG水平,值得临床上推广应用。
Objective To observe the clinical effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods 82 patients with ectopic pregnancy admitted from November 2012 to November 2014 were randomly divided into control group and observation group, 41 cases each. Control group intramuscular injection of methotrexate 50 mg / m2, 2 times / d, once every 3 d. The observation group on the basis of the control group, oral mifepristone 50 mg / time, 2 times / d, once every 3 d. Observed and compared the efficacy of two groups, pregnancy mass size, progesterone and β-HCG levels. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 70.7% in the control group and 92.7% in the observation group. The difference between the two groups was statistically significant (χ2 = 6.609, P <0.05). After treatment, the size of pregnancy mass, progesterone and β-HCG levels in control group were (2.13 ± 0.28) cm, (25.29 ± 3.76) ng / ml and (894.13 ± 46.10) U / 0.95 ± 0.17) cm, (3.34 ± 1.12) ng / ml and (316.95 ± 21.09) U / L, respectively. There was significant difference between the two groups (t = 23.066, 35.824, 72.902, all P <0.05). Conclusion Methotrexate combined with mifepristone treatment of ectopic pregnancy good effect, can significantly reduce the size of pregnancy lesions mass, reduce the level of progesterone and β-HCG, worthy of clinical application.