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目的探讨男性乳腺癌的临床特征及合理的临床治疗。方法对1986年至1999年间收治的23例男性乳腺癌进行回顾性分析,其中行乳腺癌根治术16例(69.6%),改良根治术4例(17.4%),3例因为心脏原因仅行局部切除术(13.0%);2例Ⅱ期、3例Ⅲ期患者行术前化疗,23例行术后化疗;14例行术后放疗;3例行术后内分泌治疗。结果经过4~216个月的随访,5年总生存率为73.9%,无瘤生存率为60.9%;10年总生存率63.6%,无瘤生存率为45.5%。在预后相关指标单因素分析中,未能发现年龄、肿瘤大小、临床分期、腋淋巴结转移等因素对预后产生影响。结论男性乳腺癌的治疗应采取手术治疗、化疗、内分泌治疗、放疗相结合的综合治疗措施。
Objective To investigate the clinical features and reasonable clinical treatment of male breast cancer. Methods A retrospective analysis was performed on 23 cases of male breast cancer admitted between 1986 and 1999. Among them, 16 cases (69.6%) underwent radical mastectomy, 4 cases (17.4%) underwent modified radical mastectomy and 3 cases underwent local excision Resection (13.0%); 2 cases of stage Ⅱ, 3 cases of stage Ⅲ preoperative chemotherapy, 23 cases of postoperative chemotherapy; 14 cases of postoperative radiotherapy; 3 cases of postoperative endocrine therapy. Results After 4 to 216 months of follow-up, the overall 5-year survival rate was 73.9% and the tumor-free survival rate was 60.9%. The 10-year overall survival rate was 63.6% and the tumor-free survival rate was 45.5%. Univariate analysis showed that prognosis was not affected by age, tumor size, clinical stage and axillary lymph node metastasis. Conclusion The treatment of male breast cancer should be treated with surgery, chemotherapy, endocrine therapy, radiotherapy combination of comprehensive treatment measures.