论文部分内容阅读
目的探讨液基超簿技术(TCT),高危型HPV检查及宫价值。方法对2009年8月—2010年5月,在安徽省淮南市红十字朝阳医院就诊的5 400例患者进行TCT检查,按Bethesda系统(TBS)细胞学分类诊断。对TCT检查结果异常者,包括不典型鳞状细胞(ASC-US)以上的病变者,取宫颈分泌物作高危型HPV检查。在阴道镜下行宫颈多点活检,并进行病理诊断。结果 5 400例患者中TCT结果异常281例,占总标本数的5.20%,其中意义不明的不典型鳞状细胞(ASC-US)49例,占总阳性例数的17.44%;不能排除高度上皮内病变的不典型鳞状细胞(ASC-H)58例,占总阳性例数的20.64%;鳞状上皮内低度病变(LSIL)98例,占总阳性例数的34.88%;鳞状上皮内高度病变(HSIL)73例,占总阳性例数的25.98%;宫颈鳞癌3例,占总阳性例数的1.07%。对281例检查结果异常患者,宫颈活检病理结果:炎症占6.76%(19/281);宫颈上皮内瘤变(CIN)占92.17%(259/281),其中CINⅠ125例,CINⅡ94例,CINⅢ40例;鳞状细胞癌占1.07%(3/281)。在281例中,高危型HPV(+)占89.32%(251/281)。CIN中HPV感染率为94.98%(246/259)。结论 TCT技术结合TBS应用是初步筛查和诊断宫颈癌前病变的手段,CIN患者高危型HPV阳性率较高,宫颈活组织病理检查,才是宫颈癌前病变的最后检查。
Objective To investigate the technique of liquid base super-book (TCT), high-risk HPV test and the value of uterus. Methods From August 2009 to May 2010, 5 400 patients treated in Red Cross Chaoyang Hospital of Huainan City, Anhui Province were studied by TCT and diagnosed according to the cytology of Bethesda system (TBS). For TCT abnormalities, including atypical squamous cells (ASC-US) above lesions, take cervical secretions for high-risk HPV test. Cervical colposcopy under biopsy, and pathological diagnosis. Results There were 281 out of 5 400 patients with TCT abnormalities, accounting for 5.20% of the total number of cases. Among them, 49 cases of ASC-US with unknown significance accounted for 17.44% of total positive cases; There were 58 cases of atypical squamous intraepithelial lesion (ASC-H), accounting for 20.64% of the total positive cases, 98 cases of LSIL (34.88%), squamous epithelium There were 73 cases of internal stricture (HSIL), accounting for 25.98% of the total positive cases; 3 cases of cervical squamous cell carcinoma, accounting for 1.07% of the total positive cases. Cervical biopsy results showed that inflammation accounted for 6.76% (19/281), cervical intraepithelial neoplasia (CIN) accounted for 92.17% (259/281), including CINⅠ125 cases, CINⅡ94 cases and CINⅢ40 cases. Squamous cell carcinoma accounted for 1.07% (3/281). In 281 cases, high-risk HPV (+) accounted for 89.32% (251/281). The HPV infection rate in CIN was 94.98% (246/259). Conclusion TCT combined with TBS is a preliminary screening and diagnosis of cervical precancerous lesions, CIN patients with high-risk HPV positive rate, cervical biopsy, is the final examination of cervical precancerous lesions.