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目的探讨Clara细胞分泌蛋白(CCSP)检测在儿童哮喘中的临床意义。方法采用酶联免疫吸附法检测50例哮喘急性发作期患儿血清CCSP水平,其中22例患儿经治疗后于缓解期采血复查,另设20例健康儿童作对照。结果哮喘急性发作期、缓解期患儿血清CCSP水平均较健康对照组显著降低(P<0.001,0.01)。中重度发作哮喘患儿,血清CCSP浓度显著低于轻度发作的哮喘患儿(P<0.001)。病程长的哮喘患儿CCSP水平显著低于病程短者(P<0.05)。结论CCSP具有抗感染作用,CCSP的减少可诱导或加重哮喘儿童的呼吸道炎症。检测血清CCSP是反映小呼吸道Clara细胞受损的一种非侵入性方法;CCSP可作为判断哮喘病情、治疗效果及预后的指标之一。
Objective To investigate the clinical significance of Clara cell secretory protein (CCSP) detection in childhood asthma. Methods Serum CCSP levels were measured in 50 children with acute asthma attack by enzyme-linked immunosorbent assay (ELISA). Twenty-two children underwent reabsorption after remission and 20 healthy children as controls. Results The levels of serum CCSP in acute asthmatic children and remission children were significantly lower than those in healthy controls (P <0.001, 0.01). Serum CCSP was significantly lower in children with moderate-to-severe asthma than in mild-onset asthma (P <0.001). CCSP levels in asthmatic children with longer duration were significantly lower than those with shorter duration (P <0.05). Conclusions CCSP has an anti-infective effect. The decrease of CCSP can induce or aggravate respiratory inflammation in asthmatic children. Detection of serum CCSP is a non-invasive method to reflect the damage of Clara cells in small airways. CCSP can be used as one of the indicators to judge the condition, treatment effect and prognosis of asthma.