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目的:研究乙酰水杨酸钙脲的抗炎、抗胃粘膜刺激作用,为临床应用提供理论基础。方法:应用角叉菜胶足肿胀和棉球肉芽肿模型,观察了乙酰水杨酸钙脲的抗炎作用并对胃溃疡的形成进行了观察。结果:乙酰水杨酸钙脲具有非常明显的抗炎作用,对胃粘膜的刺激作用远较乙酰水杨酸轻。结论:乙酰水杨酸钙脲可成为乙酰水杨酸最好的替代药品。
Objective: To study the anti-inflammatory and anti-gastric mucosal stimulating effects of calcium salicylate and provide the theoretical basis for clinical application. Methods: The carrageenan foot swelling and cotton ball granuloma model was used to observe the anti-inflammatory effect of acetylsalicylic acid and the formation of gastric ulcer was observed. Results: Calcium salicylate showed obvious anti-inflammatory effect and less irritation to gastric mucosa than acetylsalicylic acid. CONCLUSION: Acetylsalicylic acid calcium urea can be the best alternative medicine of acetylsalicylic acid.