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目的探讨高血压患者腰臀比(WHR)与动态动脉硬化指数(AASI)的关系,为预防心血管疾病提供依据。方法于2013年10月至2015年10月选取兰州大学第二医院急诊及住院确诊的高血压患者288例作为研究对象,根据WHR值(男性<0.90,女性<0.85)将患者分为对照组154例和腹型肥胖组134例。测量两组患者的体重、腰围(WC)、臀围,并计算WHR,采用常规24 h动态血压监测数据测定及计算AASI,同时检测空腹血糖、血脂水平。应用SPSS 19.0软件包进行Pearson相关分析及多元线性回归分析。结果与对照组相比较,腹型肥胖组性别比、体质指数(BMI)、WC、24 h平均收缩压(24 h-m SBP)、24 h平均舒张压(24 h-m DBP)、24 h动态脉压(24 h-APP)、24 h动态心率(24 h-AHR)和AASI均明显升高,差异均有统计学意义(P<0.05)。经Pearson相关分析,AASI与WC、BMI、WHR、24 h-m SBP、24 h-APP均呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关,多元线性回归分析表明,WC、WHR是影响AASI的独立相关因素(r值分别为0.201、0.288,P<0.01)。结论高血压患者WHR与AASI呈正相关,WHR可以作为预测高血压血管硬化的临床指标。
Objective To investigate the relationship between the ratio of waist-to-hip ratio (WHR) and dynamic arteriosclerosis index (AASI) in hypertensive patients and provide the basis for prevention of cardiovascular diseases. Methods From October 2013 to October 2015, 288 cases of emergency and hospitalized hypertensive patients in the second hospital of Lanzhou University were selected as the research object. According to WHR (male <0.90, female <0.85), patients were divided into control group 154 Cases and abdominal obesity group of 134 cases. Body weight, waist circumference (WC) and hip circumference of the two groups were measured and WHR was calculated. AASI was measured by routine 24-hour ambulatory blood pressure monitoring data and fasting blood glucose and blood lipid levels were measured. SPSS 19.0 software package was used for Pearson correlation analysis and multiple linear regression analysis. Results Compared with the control group, sex ratio, body mass index (BMI), WC, mean systolic blood pressure (24 hm SBP), 24 h diastolic blood pressure (24 hm DBP), 24 h dynamic pulse pressure 24 h-APP), 24-h dynamic heart rate (24 h-AHR) and AASI were significantly increased, the differences were statistically significant (P <0.05). A Pearson correlation analysis showed that AASI was positively correlated with WC, BMI, WHR, 24 hm SBP, 24 h-APP and negatively correlated with HDL-C. Multiple linear regression analysis showed that WC and WHR were Independent related factors (r = 0.201,0.288, P <0.01, respectively) that affected AASI. Conclusions There is a positive correlation between WHR and AASI in patients with hypertension, and WHR can be used as a clinical indicator in predicting hypertension.