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目的分析慢性肝衰竭的病因构成及影响预后的因素。方法回顾性分析110例慢性肝衰竭患者的临床资料,分析患者的病因构成情况;并根据预后将患者分为存活组61例及死亡组49例,分析可能影响预后的相关因素。结果 110例慢性肝衰竭的患者中,HBV感染占69.09%(76/110),HCV感染占8.18%(9/110),酒精性肝病占14.54%(16/110),自身免疫性肝炎占2.7%(3/110),其他原因占5.4%(6/110)。死亡组年龄≥50岁、肝硬化以及有肝性脑病、肝肾综合征、消化道出血、原发性腹膜炎及腹水患者的比率明显高于存活组(P<0.05)。结论病毒性肝炎、酒精性肝病史是罹患慢性肝衰竭的主要病因,年龄≥50岁、有肝硬化基础、合并肝性脑病、肝肾综合征、消化道出血、原发性腹膜炎及腹水可能影响患者的预后。
Objective To analyze the causes of chronic liver failure and its prognostic factors. Methods The clinical data of 110 patients with chronic liver failure were retrospectively analyzed. The etiology of the patients was analyzed. According to the prognosis, the patients were divided into survival group (n = 61) and death group (n = 49). The factors that may influence the prognosis were analyzed. Results Of 110 patients with chronic liver failure, HBV infection accounted for 69.09% (76/110), HCV infection accounted for 8.18% (9/110), alcoholic liver disease accounted for 14.54% (16/110), autoimmune hepatitis accounted for 2.7 % (3/110), for other reasons 5.4% (6/110). The death rate of patients aged> 50 years with cirrhosis and hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding, primary peritonitis and ascites was significantly higher than that of survivors (P <0.05). Conclusions The history of viral hepatitis and alcoholic liver disease is the main cause of chronic liver failure. The patients with the age of over 50 years old have the basis of cirrhosis, combined hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding, primary peritonitis and ascites The patient’s prognosis.