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目的:探讨非转移性黑色素瘤糖蛋白B(glycoprotein non-metastatic melanoma protein B,GPNMB)在前列腺癌组织中的表达及其临床意义。方法:应用组织芯片结合免疫组织化学方法,检测GPNMB在63例前列腺癌组织、3例异型生前列腺组织、8例良性前列腺增生组织中的表达情况,用积分光密度值(integral optical density,IOD)代表阳性细胞的表达水平。结果:GPNMB在前列腺良性增生组表达水平(IOD=70 017.49)明显低于异型增生组(IOD=10 1547.33),两组差异具有统计学意义(P=0.000 1);前列腺癌组中GPNMB的表达(IOD=162 027.54)明显高于非肿瘤组(包括良性增生和异型增生,IOD=79 290.97),两组差异具有统计学意义(P=0.000 1),但未见GPNMB的表达随着病理分级的升高而升高,病理分级低组(病理分级Ⅱ及Ⅱ以下)GPNMB表达(IOD=177 944.30)反而高于病理分级高组(病理分级Ⅱ以上,IOD=150 885.81),两组差异具有统计学意义(P=0.013)。结论:GPNMB在前列腺癌组织中的异常高表达,可能在前列腺癌的早期诊断上具有重要参考价值。
Objective: To investigate the expression of non-metastatic melanoma protein B (GPNMB) in prostate cancer and its clinical significance. Methods: The expression of GPNMB in 63 cases of prostate cancer, 3 cases of heterostatic prostate and 8 cases of benign prostatic hyperplasia were detected by tissue microarray combined with immunohistochemistry. The integral optical density (IOD) Represents the expression level of positive cells. Results: The expression of GPNMB in benign prostatic hyperplasia (IOD = 70 017.49) was significantly lower than that in dysplasia (IOD = 10 1547.33), the difference was statistically significant (P = 0.000 1) (IOD = 162 027.54) was significantly higher than non-tumor group (including benign hyperplasia and dysplasia, IOD = 79 290.97), the difference between the two groups was statistically significant (P = 0.000 1), but no expression of GPNMB with pathological grading (IOD = 177 944.30) in the low pathological grade group (pathological grade II and II) was higher than that in the high pathological grade group (pathological grade II or higher, IOD = 150 885.81). There was significant difference between the two groups Statistical significance (P = 0.013). Conclusion: The abnormally high expression of GPNMB in prostate cancer tissues may have important reference value in the early diagnosis of prostate cancer.