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目的:观察富硒超氧化物歧化酶(SOD)绿茶对糖尿病大鼠的降糖效应。方法:30只四氧嘧啶制作成功的Wistar糖尿病模型大鼠,随机分为糖尿病对照组(B组)、普通绿茶组(C组)和富硒SOD绿茶组(D组),另取10只大鼠为正常对照组(A组)。在常规饲料自由进食饮水的基础上,A组和B组给予蒸馏水灌胃,C组和D组分别给予普通绿茶粉溶液和富硒SOD绿茶粉溶液灌胃。测定大鼠空腹血糖(FPG)、糖耐量(OGTT)、糖化血清蛋白(GSP)、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活力。结果:D组大鼠分组喂养后30、60和90 d FPG和0.5、1.0、1.5、2.0 h的OGTT测定值均显著或非常显著低于C组和B组(P<0.05,P<0.01);而C组分组喂养后60和90 d后,FPG和1.5、2 h的OGTT测定值显著或非常显著低于B组(P<0.05,P<0.01);C组GSP含量显著低于B组,D组显著或非常显著低于C组和B组;C组血清SOD活性显著高于B组,D组血清SOD活力和MDA含量与B组、C组均存在显著或非常显著性差异。结论:普通绿茶和富硒SOD绿茶均具有降血糖效应,但富硒SOD绿茶效果更好,其降糖效应可能与其改善糖尿病大鼠机体抗氧化能力有关。
Objective: To observe the hypoglycemic effects of Se-enriched superoxide dismutase (SOD) green tea on diabetic rats. Methods: 30 Wistar diabetic rats were randomly divided into diabetic control group (group B), normal green tea group (group C) and selenium-enriched SOD green tea group (group D), and another 10 large Rats as a normal control group (A group). On the basis of free feed of conventional feed, group A and group B were administrated with distilled water, group C and group D were given normal green tea powder solution and selenium-enriched SOD green tea powder solution respectively. The fasting blood glucose (FPG), glucose tolerance (OGTT), glycosylated serum protein (GSP), malondialdehyde (MDA) and superoxide dismutase (SOD) Results: The FPG values at 30, 60 and 90 d after group feeding in group D were significantly lower than those in group C and group B at 0.5, 1.0, 1.5, 2.0 h (P <0.05, P <0.01) (P <0.05, P <0.01). The GG content in group C was significantly lower than that in group B at 60 and 90 d , While the activity of SOD in group C was significantly higher than that in group B. The activity of SOD and the content of MDA in group D were significantly or very significantly different from those in group B and C (P <0.05). CONCLUSION: Both normal green tea and selenium-enriched SOD green tea have the hypoglycemic effect, but the selenium-enriched SOD green tea has a better effect, and its hypoglycemic effect may be related to its ability to improve antioxidant capacity in diabetic rats.