酚妥拉明以往主要用作筛选嗜铬细胞瘤的一种药物,近年来的研究已证明该药在某些危重疾病中具有广泛的应用范围。现结合文献与我们的临床实践,特作以下综述,以供参考。一、急慢性充血性心力衰竭:心力衰竭时,交感神经兴奋性增加,使心肌收缩力加强,心率增快,并同时引起周围血管收缩。由于小静脉管经小,管壁厚,在同一强度的交感神经兴奋下,小静脉的收缩较大静脉有力,致使血液流入大静脉和肺静脉,加重心脏前负荷;小动脉收缩,动脉阻抗增加,加重心脏后负荷,促使左心室舒张末期压力升高,心排血量减少,左室射血指数下降。酚妥拉明对血管平滑肌有轻度松弛作用,但对小动脉扩张作用较强。临床应用该药可减轻心脏负荷,对急性和 Phentolamine was mainly used as a drug for the screening of pheochromocytoma in recent years. Studies in recent years have proved that the drug has a wide range of applications in some critical diseases. Now combined with the literature and our clinical practice, especially for the following review, for reference. First, acute and chronic congestive heart failure: heart failure, increased sympathetic excitability, myocardial contractility to enhance heart rate faster, and at the same time cause peripheral vasoconstriction. As the small venous by small, wall thickness, in the same intensity of sympathetic excitement, the small veins contraction larger veins, resulting in blood flow into the large veins and pulmonary veins, increased cardiac preload; arteriole contraction, increased arterial impedance, Increased cardiac load, causing left ventricular end-diastolic pressure, cardiac output decreased, decreased left ventricular ejection index. Phentolamine mild relaxation of vascular smooth muscle, but a strong role in the expansion of arterioles. Clinical application of the drug can reduce the heart load, acute and