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本文对局部用甲硝唑的化学性质、作用机制和药代动力学进行了综述,并对本品的使用和药效、副作用、治疗酒渣鼻时的剂量、服法进行了讨论。化学性质甲硝唑是一合成的抗菌和抗原虫药物。本品为白色至淡黄色结晶或结晶性粉末,微溶于乙醇,30℃水中溶解度为11.4mg/ml,供局部使用。美国制成含对羟苯甲酸丙酯和丙二醇的甲硝唑水凝胶。作用机制本品降解后的产物有抗微生物作用包括破坏DNA及抑制核酸合成。甲硝唑对酒渣鼻病损和红斑的改善作用,其机
This article reviewed the chemical properties, mechanism and pharmacokinetics of metronidazole for topical application, and discussed the use and efficacy, side effects, dosage and treatment of rosacea. Chemical properties Metronidazole is a synthetic antibacterial and anti-protozoal drugs. This product is white to pale yellow crystalline or crystalline powder, slightly soluble in ethanol, 30 ℃ water solubility of 11.4mg / ml, for local use. The United States made metronidazole hydrogel containing propylparaben and propylene glycol. Mechanism of action The product after degradation of antimicrobial effects include DNA damage and inhibition of nucleic acid synthesis. Metronidazole on rosacea lesions and erythema to improve the role of its machine