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作为一种延续后代的重要辅助手段，人类辅助生殖技术（assisted reproductive technology，ART）在临床的应用越来越广泛。胚胎植入前的形态学评估和遗传学筛查是现代ART的一大重要组成部分，同时也是提高胚胎种植率和临床妊娠率的重要手段。现有的胚胎植入前遗传学筛查方法，由于其对胚胎活检的需求，安全性一直受到质疑。如何实现胚胎植入前筛查的无创性成为现阶段的研究热点。本文主要讨论了近年来一些具有临床应用价值的方法或技术，希望为无创筛查的临床应用提供参考。“,”Assisted reproductive technology (ART), as an important means of procreation, has been increasingly applied to clinical practice. Morphological evaluation and genetic screening before embryo implantation is an important part of modern ART and an essential means to improve embryo implantation rate and clinical pregnancy rate. The safety of existing preimplantation genetic screening methods has been questioned due to their needs for embryo biopsies. How to achieve non-invasive preimplantation screening has become a research hotspot at the present stage. This paper mainly discusses some methods or technologies with clinical value in recent years, hoping to provide references for the clinical application of non-invasive screening.