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目的研究正胃胶囊对胃液分泌的影响。方法制备正常大鼠胃液分泌及组胺刺激大鼠胃液分泌2个模型,正胃胶囊与对照组中药制剂(胃康灵胶囊、胃泰颗粒)、西药制剂(维U颠茄铝胶囊、铝碳酸镁片)比较,测定正胃胶囊的制酸止痛作用。结果正胃胶囊能显著抑制胃蛋白酶活力,对胃液的pH值有明显升高作用;对组胺刺激的胃液分泌量增加有明显的抑制作用;对正常大鼠胃液分泌量仅有轻度抑制作用。结论正胃胶囊在抑制胃蛋白酶活性、降低胃液pH值、抑制胃液过量分泌等有明显的临床应用优势。
Objective To study the effect of Zhengwei Capsule on gastric juice secretion. Methods Two models of gastric juice secretion and histamine-stimulated gastric secretion in normal rats were prepared. The effects of traditional Chinese medicine preparation (Weikangling capsule and Weitai granule), western medicine preparation (Victoria U belladonna aluminum capsule, Magnesium tablets) compared to determine the stomach is the acid analgesic effect. The results Zhengzheng Capsules can significantly inhibit the activity of pepsin, the pH value of gastric juice significantly increased; histamine stimulation of gastric juice secretion increased significantly inhibited the secretion of gastric juice in normal rats only mild inhibitory effect . Conclusion Zhengwei Capsule in the inhibition of pepsin activity, reduce gastric pH, inhibition of excessive secretion of gastric juice and other obvious clinical application advantages.