论文部分内容阅读
目的探讨影响酒精性脂肪肝(AFLD)患者颈动脉内膜中层厚度的因素。方法从2012年1月-2013年12月来山东省泰山医院住院及查体进行超声检测的人群中选取AFLD患者99例和53例健康对照者,均通过超声肝脏及多普勒下颈动脉斑块检测进行影响AFLD患者颈动脉内膜厚度因素的横断面研究。分组为:无颈动脉内膜中层厚度增厚的AFLD组(A组)42例;有颈动脉内膜中层厚度增厚的AFLD组(B组)57例;既无颈动脉内膜中层厚度增厚也无脂肪肝组(C组)32例;有颈动脉内膜中层厚度增厚但无脂肪肝组(D组)21例。结果 (1)AFLD组患者颈动脉内膜中层增厚发生率明显高于对照组,差异有统计学意义(χ2=4.454,P=0.035);(2)D组人群年龄高于A组、B组和C组,差异有统计学意义(P<0.05);(3)B组人群BMI明显高于C组和D组(P<0.05);A组和D组人群BMI明显高于C组(P<0.05);(4)A组和B组人群TC、TG和VLDL均明显高于C组;B组人群TC明显高于D组(P=0.044);A组和B组人群APOB明显高于C组(P<0.05);B组人群APOB明显高于D组(P=0.026);(5)A组和B组人群UA均高于C组和D组(P<0.05);(6)A组和B组人群ALT明显高于D组(P<0.05);B组人群AST明显高于C组和D组(P<0.05);A组和B组人群γ-GT均高于C组(P=0.000)和D组(P<0.05)。B组ALP高于A组(P=0.046);(7)B组人群Cr低于C组(P=0.030)。结论 AFLD患者颈动脉内膜中层厚度增厚更明显,考虑与BMI增加、脂质和UA代谢紊乱及肝肾功能的改变有关。
Objective To investigate the factors affecting carotid artery intima-media thickness in patients with alcoholic fatty liver disease (AFLD). Methods From January 2012 to December 2013, 99 patients with AFLD and 53 healthy controls were enrolled in the inpatient and physical examination of Taishan Hospital of Shandong Province. All patients underwent ultrasonic liver and Doppler carotid plaque Block detection of AFLD patients with carotid intima-media thickness of the cross-sectional study. The patients were divided into two groups: AFLD group (A group) without carotid intima-media thickness thickening in 42 cases, AFLD group (B group) with carotid artery intima-media thickness thickening in 57 cases, neither carotid artery intima-media thickness Thirty-two cases were also thick fatty liver group (C group), and there were 21 cases of thickened carotid artery intima-media thickness without fatty liver group (D group). Results (1) The incidence of carotid artery intima-media thickness in AFLD group was significantly higher than that in control group (χ2 = 4.454, P = 0.035). (2) The age of group D was higher than that of group A (P <0.05). (3) The BMI of group B was significantly higher than that of group C and D (P <0.05). The BMI of group A and group D was significantly higher than that of group C P <0.05). (4) The levels of TC, TG and VLDL in group A and group B were significantly higher than those in group C; The TC in group B was significantly higher than that in group D (P = 0.044); The APOB in group A and group B was significantly higher (P <0.05). The APOB of group B was significantly higher than that of group D (P = 0.026). (5) The UA of group A and group B were higher than those of group C and D (P <0.05) The ALT in group A and group B was significantly higher than that in group D (P <0.05). The AST in group B was significantly higher than that in group C and D (P <0.05) Group (P = 0.000) and D group (P <0.05). The ALP in group B was higher than that in group A (P = 0.046). (7) The Cr in group B was lower than that in group C (P = 0.030). Conclusions The carotid artery intima-media thickness thickening is more obvious in patients with AFLD, which may be related to the increase of BMI, the disorder of lipid and UA metabolism and the change of liver and kidney function.