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目的探讨替吉奥治疗老年胃癌患者的疗效及不良反应。方法选取2008年7月至2012年5月收治的年龄≥60岁的老年胃癌患者126例,随机分为观察组(替吉奥治疗组,63例)和对照组(63例)。观察组患者采用替吉奥胶囊治疗,对照组采用奥沙利铂联合亚叶酸钙和氟尿嘧啶方案治疗。治疗结束后,对两组患者的有效率、不良反应和治疗满意度等分别进行统计分析。结果观察组患者的总有效率为88.9%,对照组患者的总有效率为71.4%,两组差异有统计学意义(P<0.05)。患者主要的不良反应为肝功能损伤、骨髓抑制和胃肠道反应,观察组患者出现III～IV级不良反应者8例(12.7%),对照组为15例(23.8%),两组差异有统计学意义(P<0.05)。对患者的治疗满意度统计显示,观察组患者的总满意度为61.9%,对照组为55.6%,两组差异无统计学意义(P>0.05)。结论替吉奥治疗老年胃癌患者疗效显著,不良反应较低,患者满意度较高。
Objective To investigate the efficacy and adverse reactions of TIGO in the treatment of elderly patients with gastric cancer. Methods A total of 126 elderly patients with gastric cancer over 60 years old from July 2008 to May 2012 were randomly divided into observation group (63 cases) and control group (63 cases). The patients in the observation group were treated with TIGO capsules, and the control group was treated with oxaliplatin plus leucovorin and fluorouracil. After treatment, the two groups of patients were effective, adverse reactions and treatment satisfaction were statistically analyzed. Results The total effective rate was 88.9% in observation group and 71.4% in control group, the difference was statistically significant (P <0.05). The main adverse reactions in patients were liver damage, myelosuppression and gastrointestinal reaction. In the observation group, 8 cases (12.7%) had grade III-IV adverse reactions and 15 cases (23.8%) in the control group. There were significant differences between the two groups Statistical significance (P <0.05). Satisfaction statistics showed that the total satisfaction of the observation group was 61.9% and that of the control group was 55.6%. There was no significant difference between the two groups (P> 0.05). Conclusion Tigio treatment of elderly patients with gastric cancer significant effect, low adverse reactions, patients with higher satisfaction.