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目的:探讨妊娠早期促甲状腺激素(TSH)水平及甲状腺过氧化物酶抗体(TPOAb)状态与妊娠结局的关系。方法:回顾性分析2018年1月1日至2019年11月31日于东营市人民医院内分泌科或妇产科收诊的临床资料完整的孕妇2 095例。按妊娠12n ＋6周前初次检测的TSH水平分成TSH正常(0.1 μIU/ml≤TSH1)，年龄和TPOAb阳性是孕妇早产的危险因素(n OR>1，n P1]. Age and TPOAb positivity were risk factors for preterm delivery in pregnant women (n OR>1,n P<0.05).n Conclusions:TPOAb positive in early pregnancy combined with subclinical hypothyroidism in pregnancy will increase the risk of gestational diabetes, while TPOAb positive in early pregnancy combined with TSH on the high side or subclinical hypothyroidism in pregnancy will increase the risk of premature delivery, so the management of such pregnant women should be strengthened and active treatment should be given if necessary.