1 临床资料 患者,男性,47岁。1987年2月始右足背红肿伴膝关节疼痛,经对症处理,自觉症状改善。1991年5月开始发热,体温37.8～3802℃,四肢关节疼痛,严重时活动受限,足背红肿,右足背见一绿豆大皮下结节,于1990年7月25日入院。查体:T37.2℃,P 88次/min,BP16/13kPa,前额正中,鼻翼两侧,右于无名指,右足背有绿豆至蚕豆大小皮下结节,无压痛及移动性。化验:血沉78mm/1h,RF(-)。X线胸片:双肺门区可见2cm×3cm块状结节阴影。右足背皮下结节活检 1 clinical data patients, male, 47 years old. February 1987 right foot dorsal swelling and knee pain, symptomatic treatment, subjective symptoms improved. May 1991 fever, body temperature 37.8 ~ 3802 ℃, joint pain in the limbs, severe activity limitation, red dorsal foot, right foot back to see a mung bean subcutaneous nodules, on July 25, 1990 admitted. Physical examination: T37.2 ℃, P88times / min, BP16 / 13kPa, forehead, both sides of the nose, right ring finger, right foot with mung bean to bean size subcutaneous nodules, no tenderness and mobility. Assay: ESR 78mm / 1h, RF (-). X-ray: double hilar area visible 2cm × 3cm massive nodular shadows. Right dorsal subcutaneous nodules biopsy