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目的探讨肝细胞生长因子(HGF)及其受体c-Met在结直肠癌组织中的表达及其与临床病理参数之间的关系。方法采用免疫组织化学法,检测63例结直肠癌患者及20例良性腺瘤及周围正常结肠组织中HGF、c-Met的表达;计数微淋巴管密度(LMVD),分析HGF和c-Met表达及与LMVD和临床病理参数之间的关系。结果HGF与c-Met在结直肠癌组织中的阳性表达率显著高于结直肠良性腺瘤及周围正常组织(P<0.01);结直肠癌组织中LMVD明显高于对照组(U=7.94,P<0.01);HGF及c-Met阳性表达的结直肠癌组织较阴性者有更高的LMVD(P<0.01);HGF及c-Met在结直肠癌组织中的表达与淋巴结转移和TNM分期显著相关(P<0.01)。结论 HGF和c-Met与结直肠癌的发生发展密切相关,有可能成为结直肠癌治疗的新靶点。
Objective To investigate the expression of hepatocyte growth factor (HGF) and its receptor c-Met in colorectal cancer and its relationship with clinicopathological parameters. Methods Immunohistochemical method was used to detect the expression of HGF and c-Met in 63 cases of colorectal cancer and 20 cases of benign adenoma and surrounding normal colon tissue. The expression of HGF and c-Met was analyzed by counting the lymphatic vessel density (LMVD) And the relationship between LMVD and clinicopathological parameters. Results The positive rates of HGF and c-Met in colorectal cancer tissues were significantly higher than those in colorectal benign adenomas and surrounding normal tissues (P <0.01). The LMVD in colorectal cancer tissues was significantly higher than that in controls (U = 7.94, P <0.01). The expression of HGF and c-Met in colorectal cancer tissues was significantly higher than that in the patients with positive expression of HGF and c-Met (P <0.01). The expression of HGF and c-Met was correlated with lymph node metastasis and TNM stage Significantly related (P <0.01). Conclusions HGF and c-Met are closely related to the occurrence and development of colorectal cancer, which may become a new target for the treatment of colorectal cancer.