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目的探讨抗结核治疗对中晚期妊娠结核病患者的婴幼儿生长发育的影响。方法对2005年5月至2011年8月武汉市结核病防治所住院中晚期妊娠合并活动性结核病患者7例母婴的临床资料、治疗情况及随访情况进行分析,其中初治6例(强化期治疗方案HRE 3例,HREZ、HRZ、HZE各1例),复治1例(强化期治疗方案INH、PAS、PZA、Lfx、Pto)。结果7例妊娠者实际治疗时间3～12月,症状均缓解,痰菌阴转,X线胸片显示病灶明显吸收。7例分娩婴儿均存活(其中1例为早产儿),无畸形,未感染宫内结核病。随访观察婴幼儿无听力、视力损害,语言、动作、心理发育均正常。结论合理、及时的抗结核治疗不仅有利于中晚期妊娠结核病患者的临床治愈,而且对婴幼儿生长发育不良影响较小。
Objective To investigate the effect of anti-tuberculosis therapy on the growth and development of infants and young children with tuberculosis during pregnancy. Methods The clinical data, treatment and follow-up of 7 maternal and neonates with active tuberculosis who were hospitalized in Wuhan TB Hospital from May 2005 to August 2011 were analyzed. Among them, 6 were newly diagnosed 1 case of HREZ, 1 case of HREZ, 1 case of HZZ and 1 case of HZE) and 1 case of rehospitalization (INH, PAS, PZA, Lfx, Pto). Results The actual treatment time of 7 cases of pregnancy was 3 ~ 12 months, the symptoms were relieved, sputum negative conversion, X-ray showed obvious absorption of lesions. 7 cases of childbirth were alive (1 case of premature children), no deformity, not infected with intrauterine tuberculosis. Follow-up observation of infants and young children without hearing loss, visual impairment, language, movement, mental development were normal. Conclusion The reasonable and timely anti-TB therapy is not only beneficial to the clinical cure of TB patients in middle and late pregnancy, but also has little effect on the growth and development of infants and young children.