体外培养的未经克隆化的牙周韧带细胞是具有多种细胞表型的细胞群。按照细胞的分化潜能,可分为成纤维细胞表型和成骨样细胞表型。其中,成骨样细胞表型又可分为成牙骨质细胞表型和成骨细胞表型。笔者就牙周韧带细胞不同细胞表型的表面标记物(surface marker)、表型分化的影响因素以及细胞克隆在表型研究中的应用作一综述。 Cultured non-cloned periodontal ligament cells are populations of cells that have multiple cell phenotypes. According to the differentiation potential of cells, it can be divided into fibroblast phenotype and osteoblast-like cell phenotype. Among them, osteoblast-like cell phenotype can be divided into osteoblast phenotype and osteoblast phenotype. The authors reviewed the surface markers of different cell phenotypes of periodontal ligament cells, the influencing factors of phenotypic differentiation and the application of cell cloning in phenotypic studies.