有关大鼠局灶性脑缺血的动物模型,已经建立有几种,如经颅底直接电凝大脑中动脉(MCA)法、光化学诱导法和插线法等。其中插线法由于可将已抗凝处理的插线拔出而具有可恢复再灌流的优点,因而被越来越多的研究者采用。插线法同时也避免了开颅过程对大鼠的创伤,因此也使结果减少了创伤因素的干扰。此法由Koizumi等于1986年首次发表,以后Nagasawa对本模型的组织学改变与脑血流的(CBF)相关性作了探讨,同年Longa对本模型的变异情况做了研究并成功地在体重300～400g的大鼠中建 Several animal models of focal cerebral ischemia in rats have been established, such as direct transcranial middle cerebral artery (MCA), photochemical induction and patchwork. Among them, the plug-in method has the advantage of being capable of recovering and re-perfusion because it can pull out the anticoagulant-treated cord and is therefore used by more and more researchers. The plug-in method also avoids the traumatic injury of the rat during craniotomy and therefore reduces the interference of traumatic factors. This method was first published in 1986 by Koizumi et al. Later, Nagasawa discussed the relationship between histological changes and cerebral blood flow (CBF) in this model. In the same year, Longa studied the variation of this model, The rats in the built