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目的检测肿瘤易感基因TSG101在肉瘤的表达情况,探讨其表达在肉瘤发生中的可能作用。方法福尔马林固定、石蜡包埋40例肉瘤标本进行HE和TSG101免疫组织化学染色,观察TSG101的表达情况。结果肿瘤易感基因TSG101在肉瘤中的表达率较低,仅为17.5%。结论TSG101基因的缺陷可能是间叶组织来源恶性肿瘤的常发事件,其表达情况与恶性上皮组织肿瘤中的显著差异对两者的鉴别诊断可能有帮助。
Objective To detect the expression of tumor susceptibility gene TSG101 in sarcoma and to explore its possible role in the carcinogenesis of sarcoma. Methods 40 formalin - fixed and paraffin - embedded specimens of sarcomas were harvested for HE and TSG101 immunohistochemical staining to observe the expression of TSG101. Results The expression rate of TSG101 was low in sarcoma, only 17.5%. Conclusions The defect of TSG101 gene may be a frequent event in mesenchymal malignant tumor. The significant difference between the expression of TSG101 gene and the malignant epithelial tumor may be helpful for the differential diagnosis of both.