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1 病例报告例1男,35岁。患十二指肠溃疡(DU),于1989-10-02口服西咪替丁(Cim)1g/d 冶疗。服药10 d 后自觉心慌、头昏。心率42次/min,律齐,无杂音。心电图示窦性心动过缓。考虑Cim 的毒性反应,立即停药,3d 后自觉症状消失,查体未见异常,复查心电图正常。在严密观察下属其再服 Cim(1g/d),次日患者又觉心慌、头昏,心率44次/min,律齐,心电图示窦性心动过缓。例2女,28岁。因患胃溃疡(GU)于1991-04-06口服Cim 1g/d 治疗。服药18d 出现心慌、气促,心率50次/min,心律不规则。心电图示二度房室传导阻滞文氏现象。停用 Cim,5d 后自觉症状消失,复查心电图正常。为了验证二度房室传导阻滞文氏现象是否由 Cim 所致,嘱其再服 Cim(1g/d),4d后又出现心慌、气促,心率50次/min,心律不规则。心电图示
1 case report 1 male, 35 years old. Duodenal ulcer (DU), 1989-10-02 oral cimetidine (Cim) 1g / d treatment. 10 d after taking a conscious palpitation, dizziness. Heart rate 42 beats / min, law Qi, no noise. ECG shows sinus bradycardia. Considering the toxicity of Cim, immediate withdrawal, symptoms disappeared after 3d, physical examination showed no abnormality, review of normal ECG. In the close observation of subordinates its service Cim (1g / d), the next day the patient feels flustered, dizziness, heart rate 44 beats / min, law Qi, ECG shows sinus bradycardia. Example 2 Female, 28 years old. Due to gastric ulcer (GU) in 1991-04-06 oral Cim 1g / d treatment. Medication 18d palpitation, shortness of breath, heart rate 50 beats / min, irregular heart rhythm. ECG second room AV block Wen’s phenomenon. Disable Cim, symptoms disappear after 5d, normal ECG review. In order to verify whether the second-degree AV block Wen’s phenomenon caused by Cim, Huanzhe its Cim (1g / d), 4d and then appeared palpitation, shortness of breath, heart rate 50 beats / min, irregular heart rhythm. ECG illustration