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目的 评价卡介苗多糖核酸对慢性阻塞性肺疾病 (COPD)患者呼吸道感染的预防作用。方法 148例COPD患者随机分为预防组及对照组 ,预防组在一般治疗的基础上加用肌注卡介苗多糖核酸 0 5mg ,每周 2次 ,共 18次 ,对照组仅用一般治疗。两组患者每 2周门诊随访 1次 ,记录呼吸道感染次数、天数 ,于用药前、用药后 4周、2 4周查血清IgA、IgG、IgM ,共观察 6个月。结果 预防组呼吸道感染例数、感染天数及未发生感染率均明显低于对照组 (P <0 0 1)。结论 卡介苗多糖核酸对COPD患者有预防呼吸道感染的作用 ,减少复发次数 ,缓解患者病情
Objective To evaluate the preventive effect of BCG-PSN on respiratory infection in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 148 patients with COPD were randomly divided into prophylaxis group and control group. The prophylaxis group was treated with intramuscular BCG 0 05mg twice a week for 18 times. The control group was treated only with general treatment. Two groups of patients were followed up every 2 weeks. The number of respiratory infections and days were recorded. Serum IgA, IgG, and IgM levels were measured before treatment, 4 weeks and 24 weeks after treatment, and were observed for 6 months. Results The number of respiratory tract infections, the number of infection days and the rate of non-infection in prevention group were significantly lower than those in control group (P <0.01). Conclusion Bacillus Calmette-Guérin polysaccharide nucleic acid can prevent respiratory tract infection in patients with COPD, reduce the number of relapse and relieve the patient’s condition