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目的:探究不同血清检测方法用于梅毒检验的临床价值。方法:随机纳入2013年1月至2016年1月我站收治的梅毒患者80例,作为试验组,同时纳入80例非梅毒患者作为对照组,采用酶联免疫吸附试验(ELISA)、螺旋体明胶颗粒凝集试验(TPPA)、甲苯胺红不加热血清试验(TRUST)三种方法进行梅毒检测,比较三种方法的特异度和灵敏度及检测结果。结果 :ELISA法和TRUST法检测结果相比较,P<0.05,具有统计学差异,TPPA法和TRUST法检测结果相比较,P<0.05,具有统计学差异;TPPA法和ELISA法检测结果相比较,P>0.05,没有统计学差异。ELISA法、TPPA法和TRUST法的灵敏度分别为96.3%、100.0%和80.0%。结论 :ELISA法可用于梅毒的筛查;TRUST法用于梅毒治疗效果的观察;TPPA法可用于梅毒的确诊检测,三种方法同时使用可以降低误诊率和漏诊率,对于梅毒患者具有重要临床价值。
Objective: To explore the clinical value of different serum test methods for syphilis test. Methods: Totally 80 patients with syphilis admitted to our hospital from January 2013 to January 2016 were enrolled in the study. 80 non-syphilis patients were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA), spirochete gelatin granules Conjugation test (TPPA), Toluidine red unheated serum test (TRUST) three methods for syphilis detection, comparison of three methods of specificity and sensitivity and test results. Results: The difference between ELISA and TRUST was significant (P <0.05). There was significant difference between the ELISA and TRUST, the difference between TPPA and TRUST was statistically significant (P <0.05) P> 0.05, no statistical difference. The sensitivity of ELISA, TPPA and TRUST were 96.3%, 100.0% and 80.0% respectively. Conclusion: ELISA can be used for the screening of syphilis; TRUST method for the treatment of syphilis; TPPA method can be used for the diagnosis of syphilis, the three methods can reduce the rate of misdiagnosis and misdiagnosis, has important clinical value for patients with syphilis .