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癌基因和抗癌基因的异常是肿瘤发生的主要机制，已在口腔癌中发现某些癌基因的激活和抗癌基因的失活。本文对口腔癌与ｒａｓ、ｍｙｃ、ｅｒｂＢ＿２癌基因及Ｐ５３抗癌基因的关系作一综述。
Abnormalities of oncogenes and anti-oncogenes are the major mechanisms of tumorigenesis. The activation of certain oncogenes and the inactivation of anti-oncogenes have been found in oral cancers. This article reviews the relationship between oral cancer and ras, myc, erbB2 oncogene and P53 anti-oncogene.