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目的探讨不同三联疗法对Hp阳性的小儿消化性溃疡的治疗效果。方法将我院64例Hp阳性的消化性溃疡患儿随机分为治疗组和对照组各32例,治疗组给予克拉霉素、奥美拉唑和甲硝唑治疗,对照组给予阿莫西林、奥美拉唑和甲硝唑治疗,治疗周期均为14d。分析比较两组患儿治疗后临床疗效。结果治疗组Hp根除率、溃疡愈合率均明显高于对照组,组间差异有统计学意义,P<0.05。结论克拉霉素三联疗法治疗Hp阳性小儿消化性溃疡,能有效根除Hp,促进溃疡面愈合,临床疗效令人满意,值得临床推广应用。
Objective To investigate the therapeutic effect of different triple therapy on Hp-positive pediatric peptic ulcer. Methods Sixty-four children with Hp-positive peptic ulcer in our hospital were randomly divided into treatment group (32 cases) and control group (32 cases). The treatment group was treated with clarithromycin, omeprazole and metronidazole, while the control group was given amoxicillin, Omeprazole and metronidazole treatment, the treatment cycle are 14d. Analysis of two groups of children after treatment clinical efficacy. Results Hp eradication rate and ulcer healing rate were significantly higher in the treatment group than in the control group, with significant difference between the two groups (P <0.05). Conclusion Clarithromycin triple therapy in children with Hp-positive peptic ulcer can effectively eradicate Hp and promote ulcer healing, the clinical efficacy is satisfactory, worthy of clinical application.