自从Robert Koch使用Mtb培养滤液疫苗(旧结核菌素)治疗人类结核病出现“郭霍现象”(Koch phenomenon)、许多患者临床表现恶化、少数患者死亡之后,结核病疫苗治疗研究受到重创,直到化疗药物的出现人们仍然未找到有效的免疫治疗方法。化疗药物的治疗效果和结核病控制策略的成功曾经使人们欣喜若狂,但20世纪80年代后结核病低流行率的西方国家结核病重新抬头和上升,随后全球耐多药 Since Robert Koch used the Mtb culture filtrate vaccine (old tuberculin) to treat the “Koch phenomenon” of human TB in many patients, the clinical manifestations of many patients have deteriorated. After a small number of patients have died, the TB vaccine treatment study has been hit hard until chemotherapy The emergence of drugs People still do not find effective immunotherapy methods. The success of chemotherapeutic agents and tuberculosis control strategies has made people ecstatic, but Western countries have seen a rise in the number of tuberculosis in Western countries with a low prevalence of TB after the 1980s, followed by global multidrug-resistant