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叶酸的化学结构为喋酰谷氨酸(Pterylglutamic acid),其辅酶型的四氢叶酸(Jetrahrdrorolic acid)在体内对嘌呤及嘧啶的代谢、蛋氨酸的合成、酪氨酸及色氨酸的羟化等,都起重要的作用。临床熟知,叶酸缺乏是巨幼红细胞性贫血的原因;近年来,叶酸缺乏症和抗癫痫药的关系也受到人们的重视。1950年有人报告,抗癫痫药引起巨幼红细胞性贫血;后来大部分报告又反复确认了服用抗癫痫的患
The chemical structure of folic acid is Pterylglutamic acid. Its coenzyme type of Jetrahrdrorolic acid metabolizes purine and pyrimidine, synthesis of methionine, hydroxylation of tyrosine and tryptophane in vivo , All play an important role. Clinical well-known, folic acid deficiency is the cause of megaloblastic anemia; in recent years, the relationship between folic acid deficiency and antiepileptic drugs have also been people’s attention. It was reported in 1950, antiepileptic drugs cause megaloblastic anemia; most reports have repeatedly confirmed after taking epilepsy