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聚乙烯醇(polyvinyl alcohol,PVA,型号 0588)是一种水溶性可被机体吸收的高分子材料。作为女性避孕药膜的基质已用于临床。为评价其对人体的安全性,进行了致畸胎的毒性研究。 选用昆明种?小鼠,体重22～25 g,每组20～25只,共四组。实验分为 300 mg/kg和150 mg/kg二个剂量组,容积均为0.5 ml阴道注入,每日一次,连续60次。对照组分为生理盐水溶剂组和含敌枯双浓缩鱼肝油阳性对照组。给药方法同实验组。按2:1??同罐交配,每日查阴道栓两次,如发现阴道栓者,即确定为妊娠“0”
Polyvinyl alcohol (PVA, Model 0588) is a water-soluble polymer that can be absorbed by the body. As a female contraceptive membrane matrix has been used clinically. To evaluate its safety to humans, teratogenic toxicity studies were conducted. Selected Kunming species? Mice, weighing 22 ~ 25 g, each group of 20 to 25, a total of four groups. The experiment was divided into two dose groups of 300 mg / kg and 150 mg / kg, the volume of which was 0.5 ml vaginal injection once a day for 60 times. The control group consisted of saline solvent group and positive control group with double-concentrated cod liver oil. The method of administration is the same as the experimental group. Press 2: 1 ?? with the tank mate, check the vaginal suppository twice a day, found vaginal suppository, that is identified as pregnancy “0”