论文部分内容阅读
结直肠锯齿状腺癌是结直肠癌的一种亚型,其发病率约占结直肠癌的7.5%,具有独特的组织学与病理学特点,包括癌组织呈浸润性生长,隐窝上皮呈锯齿状形态,胞质呈嗜酸性或嗜中性,具有空泡样核,核质比例低等。锯齿状腺癌分为锯齿状、黏蛋白状、小梁状三种生长模式。其产生机制主要沿两条锯齿状通路即传统锯齿状通路和广基锯齿状通路。该文主要就结直肠锯齿状腺癌的临床病理学特点及诊断标准、发病机制、预后等方面做一概述。
Colorectal serrated adenocarcinoma is a subtype of colorectal cancer, its incidence rate of about 7.5% of colorectal cancer, has a unique histological and pathological features, including invasive growth of cancer tissue, crypt epithelium was Jagged morphology, cytoplasm eosinophilic or neutrophilic, with vacuolar nucleus, a low proportion of nuclear matter. Serrated adenocarcinoma is divided into jagged, mucinous, trabecular like three growth patterns. The mechanism is mainly along the two serrated path that is the traditional serrated path and wide-based serrated path. This article mainly summarizes the clinicopathological features, diagnostic criteria, pathogenesis and prognosis of the serrated colorectal serosa.