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糖尿病性类脂质渐进性坏死(NLD)是有临床特征的少见皮肤病,累及0.3%的糖尿病病人,但也可见于非糖尿病患者。组织病理可见真皮胶原肿胀和扭曲。NLD 尚无满意的治疗方法。糖尿病的治疗和NLD 及其它糖尿病并发症的关系仍不清楚。作者对15例并发NLD 的糖尿病患者进行了研究,从临床病理方面评价NLD 患者的微血管和神经系统并发症的发生率。15例NLD 中,Ⅰ型糖尿病14例,Ⅱ型1例;男1例,女14例。在糖尿病确诊前均无NLD,患糖尿病后诊断有NLD 的平均期限为7.7年。临床上所有NLD 患者,通过对皮损边缘的痛觉、轻触觉及踝反射、神经电生理检查,证实
Diabetic lipids Progressive necrosis (NLD) is a clinically characterized rare skin disease involving 0.3% of diabetic patients, but also in non-diabetic patients. Histopathology showed dermal collagen swelling and distortion. NLD yet satisfactory treatment. The relationship between the treatment of diabetes and NLD and other complications of diabetes remains unclear. The authors studied 15 diabetic patients with NLD and evaluated the incidence of microvascular and neurologic complications in patients with NLD from a clinicopathological point of view. In 15 cases of NLD, 14 cases were type 1 diabetes mellitus and 1 case was type II, including 1 males and 14 females. There was no NLD before diabetes was diagnosed, and the mean duration of NLD diagnosis after diabetes was 7.7 years. All clinical patients with NLD, pain through the edge of the skin lesions, touch and ankle reflex, neuroelectrophysiology, confirmed