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目的:探讨血管紧张素Ⅱ受体拮抗剂(ARB)对PAF患者P波离散度的影响。方法:观察48例阵发性AF患者的最宽P波和P波离散度,并与ARB干预治疗3个月后进行对比分析。结果:ARB治疗3个月后最宽P波、P波离散度及P波离散度≥40 ms的例数与治疗前比较差异有统计学意义(P<0.05或<0.01)。结论:ARB能减轻PAF患者心房结构重构及电重构,减少AF的发生。
Objective: To investigate the effect of angiotensin Ⅱ receptor antagonist (ARB) on P wave dispersion in PAF patients. Methods: The maximal P wave and P wave dispersion in 48 patients with paroxysmal AF were observed and compared with ARB interventions for 3 months. Results: The maximum P wave, P wave dispersion and P wave dispersion ≥40 ms after ARB treatment for 3 months were significantly different from those before treatment (P <0.05 or <0.01). Conclusion: ARB can reduce atrial structural remodeling and electrical remodeling of PAF patients and reduce the occurrence of AF.