论文部分内容阅读
作者对11例停服抗过敏药1周以上,对螨过敏的变应性鼻炎患者自下鼻甲取鼻粘膜标本,包括粘膜全层,切成1mm见方的薄片,置营养液中,加入螨抗原,使其最终浓度分别为10μg/ml,1μg/ml及0.1μg/ml。另一组加入不同浓度的P物质,属非特异性刺激。对照组则加入PAGCM液。分别测定上清液中组胺和白三烯含量。结果:螨抗原刺激及P物质刺激后上清液中组胺含量均增加,与对照组比较差异显著。重症病例较中等重病例组胺游离率高。螨抗原刺激后白三烯释放增加,LTs及LTB_4于重症病例较中等重病例游离率高,白三烯与组
The authors of 11 patients stopped taking anti-allergy drugs for more than 1 week, allergic rhinitis allergic rhinitis patients from the nasal mucosa nasal mucosa specimens, including mucosal layers, cut into 1mm square slices, set nutrient solution, add mite antigen The final concentrations were 10 μg / ml, 1 μg / ml and 0.1 μg / ml, respectively. The other group added different concentrations of substance P, is a non-specific stimulation. The control group was added PAGCM solution. The contents of histamine and leukotriene in the supernatant were measured respectively. Results: The contents of histamine in supernatant stimulated by mite antigen and substance P increased significantly compared with the control group. Severe cases than moderate cases of high histamine free rate. Mite antigen stimulation leukotriene release increased, LTs and LTB_4 in severe cases than in moderate cases of high free rate, leukotrienes and group