论文部分内容阅读
自从化学药物用于治疗肿瘤以来,使部份病人得以缓解,生存期延长,同时也发现有些抗癌药物有致癌作用。动物实验已证实有致癌作用的抗癌药物有:氮芥、环磷酰胺、马利兰、瘤可宁、左旋溶肉瘤素、噻替派、甲基苄肼、三乙烯聚氢胺、脲嘧啶氮芥、乌拉坦、柔红霉素、卡氮芥、异磷胺、二溴甘露醇、链脲霉素、阿特里亚霉素、硝基脲、丝裂霉素、放线菌素D等(1～13)。临床上亦观察到有些肿瘤病人如慢性粒细胞型白血病(14～19),慢性淋巴细胞型白血病(41,47,48),急性淋巴细胞型白血病(47～51),急性干细胞型白血病(52),多发性骨髓瘤(20～30),何杰金氏病(35～42)、淋巴肉瘤(43～45)、网状细胞肉瘤(52)、真性红细胞增多症(31～34)、
Since the chemical drugs used to treat tumors, some patients have been alleviated, prolonged survival, but also found that some anti-cancer drugs have carcinogenic effects. Animal experiments have proven carcinogenic anticancer drugs are: nitrogen mustard, cyclophosphamide, Maryland, tumor Ning, levosarcoma, thiophene, procarbazine, trimethoprim, uracil mustard , Urethane, daunorubicin, carmustine, isophosphamide, dibromomanitol, streptozotocin, atriomycin, nitrosourea, mitomycin, actinomycin D and the like 1 ~ 13). Some tumor patients are also clinically observed, such as chronic myeloid leukemia (14-19), chronic lymphocytic leukemia (41,47,48), acute lymphoblastic leukemia (47-51), acute stem cell leukemia ), Multiple myeloma (20-30), Hodgkin’s disease (35-42), lymphosarcoma (43-45), reticulocytic sarcoma (52), polycythemia vera (31-34)