论文部分内容阅读
[目的]分析融合灶(progressive massive fibrosis,PMF)总体积(V_(PMF))与肺功能的相关性,探讨V_(PMF)对叁期尘肺患者肺功能评价的意义,为临床评估叁期尘肺病患者的肺功能提供参考。[方法]收集2016年1—9月收治的叁期尘肺病并发PMF患者52例,测量患者V_(PMF),收集其肺功能指标,并对结果进行相关分析和回归分析。[结果]52例叁期尘肺病合并PMF患者肺功能主要损害特点是混合性肺通气功能障碍。患者V_(PMF)范围为5.63~258.8 cm~3;与其第一秒用力呼气量占预计值比值(FEV_1/Pre)、用力肺活量占预计值比值(FVC/Pre)、肺一氧化碳弥散量占预计值比值(DLCO/Pre)均呈负相关(r_s=-0.74、-0.65、-0.72,P<0.05);以V_(PMF)为自变量,FEV_1/Pre、FVC/Pre、DLCO/Pre分别为应变量,进行线性回归分析所得方程分别为:FEV_1/Pre=0.87-0.003×V_(PMF)(R~2=0.58、F=68.6,P<0.01);FVC/Pre=0.91-0.002×V_(PMF)(R~2=0.45、F=41.6,P<0.01);DLCO/Pre=0.94-0.002×V_(PMF)(R~2=0.53、F=56.8,P<0.01)。[结论]可通过测量融合灶总体积大致预计FEV_1/Pre、FVC/Pre及DLCO/Pre值。
[Objective] To analyze the correlation between the total volume of PMF (V_ (PMF)) and pulmonary function, and to explore the significance of V_ (PMF) in assessing pulmonary function in patients with triple-stage pneumoconiosis. Patient’s lung function provides a reference. [Methods] Totally 52 PMF patients with pneumoconiosis complicated with PMF admitted from January to September in 2016 were collected. V PMF was measured and their pulmonary function indexes were collected. Correlation analysis and regression analysis were performed on the results. [Results] The main impairment of lung function in 52 cases of PMF patients with triple-stage pneumoconiosis was characterized by mixed pulmonary ventilation dysfunction. The V_ (PMF) ranged from 5.63 to 258.8 cm ~ 3. Compared with the FEV_1 / Pre, forced vital capacity to the predicted value (FVC / Pre) (R_s = -0.74, -0.65, -0.72, P <0.05). For V PMF as independent variable, FEV_1 / Pre, FVC / Pre, and DLCO / Pre were all negatively correlated The results of linear regression analysis were as follows: FEV_1 / Pre = 0.87-0.003 × V PMF (R ~ 2 = 0.58, F = 68.6, P <0.01); FVC / Pre = 0.91-0.002 × V_ PMF) (R ~ 2 = 0.45, F = 41.6, P <0.01); DLCO / Pre = 0.94-0.002 × V PMF (R ~ 2 = 0.53, F = 56.8, P <0.01). [Conclusion] The FEV_1 / Pre, FVC / Pre and DLCO / Pre values can be roughly estimated by measuring the total volume of fusion.