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目的观察麻仁软胶囊对便秘的疗效和对结肠黏膜的影响。方法结肠慢传输型及混合型便秘的门诊患者208例随机分为治疗组及对照组。治疗组患者每日口服麻仁软胶囊1次,每次2粒,连续服用10个月;对照组患者每日口服番泻叶5 g(沸水100 mL浸泡后顿服)1次,连续服用10个月。根据排便次数和胃肠传输实验(GITT)判断治愈率、总显效率(治愈率+显效率)、总有效率(总显效率+有效率)。依据腹胀、腹痛等判断不良反应。治疗10个月后肠镜观察结肠黏膜黑变情况。结果治疗组的治愈率略低于对照组,总显效率、总有效率与对照组无显著差异,治疗组患者服药后10个月后镜检未发现结肠黑变,而对照组26.9%患者结肠黑变。结论低剂量麻仁软胶囊治疗便秘有效,并具有较高安全性。
Objective To observe the curative effect of Maren soft capsule on constipation and its effect on colonic mucosa. Methods A total of 208 outpatients with slow transit and mixed constipation were randomly divided into treatment group and control group. Patients in the treatment group were treated with Maren soft capsules once daily for 2 months, taking 10 consecutive months. The patients in the control group were orally given 5 g of senna (100 mL immersion in boiling water) once daily for 10 consecutive days Months. According to the defecation frequency and gastrointestinal transit experiment (GITT) to determine the cure rate, the total effective rate (cure rate + significant efficiency), total effective rate (total significant efficiency + effective rate). According to bloating, abdominal pain, etc. to determine the adverse reactions. Intestinal mucosal black colonies were observed after 10 months of treatment. Results The cure rate in the treatment group was slightly lower than that in the control group. There was no significant difference between the two groups in the total effective rate and the total effective rate. In the control group, no colon melanism was observed microscopically 10 months after the medication, while in the control group, 26.9% Black change. Conclusion Low-dose hemp soft capsule is effective in treating constipation with high safety.