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[目的]了解职业接触可溶性铬盐人群尿中8-羟基脱氧鸟嘌呤(8-OHdG)含量及其影响因素,探讨其作为职业接触人群生物标志物的可行性。[方法]2006年,选择济南市某铬盐生产企业114名重铬酸钾作业的健康劳动者作为接触组,以无毒物接触史的当地健康农民30名为对照组,测定2组人群尿液中8-OHdG水平与作业环境铬盐浓度,测定接触组外周血淋巴细胞DNA链断裂水平、红细胞与尿液中铬浓度。[结果]尿液中8-OHdG水平接触组为(1240.494±1603.918)μg/L,对照组为(468.871±908.460)μg/L(P<0.01);尿液中8-OHdG水平与空气中个体铬盐暴露水平、红细胞中铬浓度水平、外周血淋巴细胞DNA链断裂水平的相关系数(r)分别为0.333、0.230、0.396(P<0.01);多元线性回归分析显示,铬盐劳动者年龄、接触铬盐的年限、空气中铬盐浓度对尿液中8-OHdG水平影响显著。[结论]尿液中8-OHdG水平可以作为职业接触可溶性铬盐劳动者遗传损伤效应性生物标志物,可望用于职业接触可溶性铬盐劳动者生物监测及健康危险性的评价。
[Objective] To investigate the urinary 8-hydroxydeoxyguanine (8-OHdG) content and its influential factors in occupational exposure to chromium salts and to explore its feasibility as a biomarker for occupational exposure. [Method] In 2006, 114 healthy workers who selected potassium dichromate in a chromium salt production plant in Jinan City were selected as the contact group. Thirty healthy local farmers with no history of exposure to poison as the control group. Urine 8-OHdG levels and working environment chromium salt concentration, determination of contact group of peripheral blood lymphocyte DNA strand breaks, erythrocytes and urine chromium concentration. [Results] The level of 8-OHdG in urine was (1240.494 ± 1603.918) μg / L in the urine and 468.871 ± 908.460 μg / L in the control group (P <0.01) The correlation coefficients (r) of chromium exposure, chromium concentration in erythrocytes and DNA strand breaks in peripheral blood lymphocytes were 0.333,0.230 and 0.396, respectively (P <0.01). Multivariate linear regression analysis showed that age, Chromium exposure to the number of years, the concentration of chromium in urine on the level of 8-OHdG significantly. [Conclusion] The 8-OHdG level in urine can be used as a genetic biomarker for occupational exposure to soluble chromium salts in workers, and it is expected to be used for biological monitoring and health risk assessment of workers exposed to chromium salts in occupational exposure.