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目的研究多囊卵巢综合征(PCOS)患者血清维生素D浓度同内分泌紊乱的相互关系。方法选取我院78例PCOS患者作为病例组,另选20例健康育龄期妇女作为对照组,计算体重指数(BMI),测定血清睾酮(T)、雌二醇(E2)、LH、FSH及血清25-(OH)D3的浓度,并进行OGTT和胰岛素释放试验,计算QUICKI指数。结果病例组25-(OH)D3浓度与BMI、T、LH/FSH呈一定的负相关,与QUICKI值呈正相关。结论维生素D缺乏与PCOS内分泌紊乱密切相关,且维生素D的紊乱可能同时与患者肥胖具有一定的相关性。
Objective To investigate the relationship between serum vitamin D concentration and endocrine disorders in patients with polycystic ovary syndrome (PCOS). Methods 78 cases of PCOS in our hospital were selected as the case group and 20 healthy women of childbearing age were selected as the control group. Body mass index (BMI), serum testosterone (T), estradiol (E2), LH, FSH and serum 25- (OH) D3 concentration, and OGTT and insulin release test, calculate the QUICKI index. Results The concentration of 25- (OH) D3 was negatively correlated with BMI, T, LH / FSH and positively correlated with QUICKI. Conclusion Vitamin D deficiency is closely related to PCOS endocrine disorders, and the disorder of vitamin D may be related to the obesity of patients at the same time.