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目的:研究国产克林霉素对临床分离的300株需氧菌和30株厌氧菌的体外抗菌活性,并与红霉素和头孢拉定作比较。方法:采用美国NCCLS推荐的琼脂稀释法测定菌株对抗菌药物的MIC(最低抑菌浓度),并以MIC_(50)、MIC_(90)和抑制百分率,表示药物的抗菌活性。结果:克林霉素对流感嗜血杆菌MIC_(50)为<0.03mg/L,与红霉素和头孢拉定相同,抑制率为88％,强于红霉素,稍弱于头孢拉定;对卡他莫拉菌的MIC_(50)为0.125mg/L,抑制率为80％,强于头孢拉定;克林霉素对甲氧西林敏感的金黄色葡萄球菌和表皮葡萄球菌MIC_(50)分别为0.125mg/L和2mg/L,远强于红霉素;对甲氧西林耐药的金黄色葡萄球菌(MRSA)MIC_(50)为1mg/L,抑制率:66.7％,强于红霉素和头孢拉定;对肺炎链球菌MIC_(50)为0.125mg/L,抑制率为77.5％,强于红霉素,稍弱于头孢他定;克林霉素对A群链球菌和B群溶血菌的MIC_(50)分别为2mg/L和0.06mg/L,抑制率为76.6％,强于红霉素,弱于头孢拉定;克林霉素对厌氧菌包括厌氧球菌、丙酸杆菌、梭杆菌和拟杆菌属,抑制率均为100％。结论:国产克林霉素对临床分离的溶血性链球菌、肺炎链球菌、甲氧西林敏感的金黄色葡萄球菌和表皮葡萄球菌、嗜血杆菌、卡他莫拉菌和厌氧菌均有良好的抗菌活性。
OBJECTIVE: To study the in vitro antibacterial activity of clindamycin on 300 aerobic and 30 anaerobic bacteria isolated from clinical isolates and to compare with erythromycin and cefradine. Methods: The antibacterial MIC (minimum inhibitory concentration) was determined by the agar dilution method recommended by the American NCCLS. The antibacterial activity of the antibacterials was determined by MIC50, MIC90 and percent inhibition. Results: Clindamycin exhibited a MIC of (0.03), which was the same as that of erythromycin and cefradine, the inhibition rate was 88%, stronger than erythromycin and slightly weaker than cefradine. The MIC 50 of Moraxella was 0.125 mg / L and the inhibition rate was 80%, which was stronger than that of cefradin. The MIC50 of Clindamycin and methicillin-sensitive Staphylococcus aureus and Staphylococcus epidermidis were 0.125 mg / L and 2mg / L, far stronger than that of erythromycin; methicillin-resistant Staphylococcus aureus (MRSA MIC_ (50) 1mg / L, inhibition rate: 66.7%, stronger than the erythromycin and cefradine ; For Streptococcus pneumoniae MIC_ (50) was 0.125mg / L, the inhibition rate was 77.5%, stronger than erythromycin, slightly weaker than ceftazidime; clindamycin group A streptococcus and group B hemolytic bacteria MIC_ (50) were 2mg / L and 0.06mg / L, the inhibition rate was 76.6%, stronger than erythromycin, weaker than cephradine; clindamycin against anaerobic bacteria including anaerobic bacteria, Propionibacterium, Fusobacterium and Fusobacterium Bacteroides, the inhibition rate was 100%. CONCLUSION: Domestic clindamycin is good for clinical isolates of hemolytic streptococcus, streptococcus pneumoniae, methicillin-sensitive Staphylococcus aureus and Staphylococcus epidermidis, Haemophilus, Moraxella catarrhalis and anaerobic bacteria Antibacterial activity.