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目的 :探讨四氧化二氮 (N2 O4)和冲击波致冲毒复合伤对动物血气的影响。方法 :雄性 Wistar大鼠16 8只 ,随机分为冲击伤组、单纯 N2 O4中毒组和冲毒复合伤组 ,每组动物分为伤前及伤后 3、6、12、2 4、48和 72小时各时间点组。冲击伤致伤方法 :将动物置于 BST I型生物激波管 ,以 471.5 k Pa冲击波冲击致伤。染毒方法 :动物置于 12 0 L 自制染毒柜 ,利用微量注射器注入液态 N2 O4,维持染毒柜内 N2 O4体积分数为 45× 10 - 6(4 5 ppm) ,造成重度染毒。结果 :3组动物动脉血氧分压 (Pa O2 )均在伤后 3～ 6小时内显著下降 ,单纯冲击伤组伤后 12小时恢复正常 ;冲毒复合伤组动物伤后动脉血 Pa O2 下降最为显著 ,重者死于呼吸衰竭。结论 :单纯冲击伤和单纯 N2 O4中毒早期血气均会有显著变化 ;冲毒复合伤对血气的影响较单纯致伤更为显著
Objective: To investigate the effects of nitrous oxide (N2 O4) and shock wave induced poisoning on animal blood gases. Methods: One hundred and sixteen male Wistar rats were randomly divided into shock injury group, N2 O4 poisoning group and compound poisoning injury group. Animals in each group were divided into three groups: pre-injury and post-injury 3,6,12,2 4,48 and 72 hours at each time point group. Impact Injury Methods: The animals were placed in a BST Type I biological shock tube and injured with a shock wave of 471.5 kPa. Methods of Exposure: The animals were housed in a self-made 120 l cabinet and injected with liquid N2 O4 using a micro syringe. The volume fraction of N2 O4 in the cabinet was maintained at 45 × 10 -6 (45 ppm), causing severe exposure. Results: The arterial partial pressure of oxygen (Pa O2) decreased significantly within 3 to 6 hours after injury in the 3 groups, and returned to normal 12 hours after the injury in the pure injury group. PaO2 decreased The most significant, severe cases of respiratory failure. Conclusions: The early blood gas of simple impact injury and simple N2 O4 poisoning all have significant changes; the impact of red blood combined injury on blood gas is more obvious than simple injury