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目的分析胎儿染色体异常核型,探讨不同产前诊断指征孕妇胎儿异常核型的检出率及对妊娠结局的指导意义。方法对不同产前指征的1029例孕妇抽取羊水培养,进行胎儿染色体核型分析,并比较各指征异常核型的检出率。结果 1029例被检孕妇中共检出胎儿异常核型39例,总异常率为3.69%(39/1029),高龄孕妇组和产前筛查高危组分别为5.02%和4.85%,其次是超声异常组3.92%,不良孕史组2.27%,其他原因组2.23%,地贫组0.53%。除地贫组,其他组间两两比较差异均无显著性差异(P>0.05),各组与地贫组比较,差异均有显著性差异(P>0.05)。结论高龄孕妇、产前筛查高危、超声异常和不良孕史是产前诊断重要指征。
Objective To analyze the karyotypes of fetal chromosomal abnormalities and to explore the detection rate of fetal abnormal karyotypes in different prenatal diagnosis indications and the guiding significance for pregnancy outcomes. Methods 1029 pregnant women with different prenatal indications were collected for amniotic fluid culture. Fetal karyotype analysis was performed. The detection rate of abnormal karyotype of each index was compared. Results A total of 1029 cases of abnormal fetal karyotypes were detected in 1029 pregnant women, with a total abnormality rate of 3.69% (39/1029), 5.02% and 4.85% respectively in the advanced pregnant women group and prenatal screening high risk group, followed by ultrasound abnormalities 3.92% in group, 2.27% in adverse pregnancy group, 2.23% in other causes group and 0.53% in thalassemia group. There was no significant difference (P> 0.05) between the other groups except for thalassemia group, and there was significant difference between each group and thalassemia group (P> 0.05). Conclusion Pregnant women, high risk of prenatal screening, abnormal ultrasound and poor pregnancy history are important indications for prenatal diagnosis.