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目的探讨神经元特异性烯醇化酶(NSE)的动态改变与脑出血患者预后的关系。方法45例脑出血患者,分别于发病24h、第3、7、15天采血,采用ELISA法测定患者血清NSE,在发病2h及第28天进行神经功能缺损评分测定,并选取健康体检者30例同法检测血清NSE作为对照。结果正常人血清中NSE水平为(4.21±0.82)μg/L,脑出血后第1天血清NSE水平即显著升高,第3天达到高峰为(8.54±1.28)μg/L,持续至第7天,其血清NSE一直维持在较高的水平,第10天明显下降,至第15天进一步降低,仍高于正常。早期NSE水平增高影响着患者的预后,升高越显著,预后越差。结论NSE可作为评定脑出血患者预后的指标。
Objective To investigate the relationship between the dynamic changes of neuron-specific enolase (NSE) and the prognosis of patients with intracerebral hemorrhage. Methods 45 cases of cerebral hemorrhage were collected on the first, the third, the seventh and the 15th day respectively. Serum NSE was measured by ELISA. Neurological deficit scores were measured at 2h and 28th days. Thirty The same method for detecting serum NSE as a control. Results The level of NSE in normal serum was (4.21 ± 0.82) μg / L, the level of serum NSE was significantly increased on the first day after cerebral hemorrhage and reached the peak at (8.54 ± 1.28) μg / L on the third day, Day, its serum NSE has been maintained at a high level, the first 10 days decreased significantly to further reduce the 15th day, still higher than normal. Early NSE levels affect the prognosis of patients, the more significant increase, the worse the prognosis. Conclusion NSE can be used as an index to evaluate the prognosis of patients with intracerebral hemorrhage.