论文部分内容阅读
目的分析2型糖尿病患者随机尿白蛋白/肌酐(ACR)与24小时尿总蛋白的相关性,探讨随机尿ACR取代24小时尿蛋白定量用于糖尿病肾病早期诊断的临床价值。方法测定200例糖尿病患者的24小时尿蛋白总量,随机尿样本中尿蛋白、肌酐含量,计算ACR。收集患者相关数据,血肌酐(Cr)、估算肾小球滤过率(e GFR),分析24h尿蛋白总量、ACR、e GFR之间的相关性。结果糖尿病患者24h尿蛋白总量与ACR的相关系数r=0.68(P<0.01),24h尿蛋白总量、ACR分别与e GFR的相关系数为r=-0.17(P<0.01),r=-0.182(P<0.01)。结论 ACR和24h尿蛋白总量之间存在良好相关性,因此ACR可以作为替代24小时尿蛋白定量检测的指标用于糖尿病肾病的早期诊断。
Objective To analyze the correlation between random urine albumin / creatinine (ACR) and 24-hour urine total protein in patients with type 2 diabetes mellitus (T2DM) and to explore the clinical value of 24-hour urinary protein (ACR) instead of random urine in the early diagnosis of diabetic nephropathy. Methods The total 24-hour urine protein and urinary protein and creatinine in 200 urine samples were measured and the ACR was calculated. Correlation data of patients, serum creatinine (Cr), estimated glomerular filtration rate (e GFR), total proteinuria 24h, ACR, e GFR were collected. Results The correlation coefficient of 24h urinary protein and ACR was 0.68 (P <0.01), and the correlation coefficient of 24 - hour urinary protein and ACR with e GFR was r = -0.17 (P <0.01), r = - 0.182 (P <0.01). Conclusion There is a good correlation between ACR and 24-h urinary protein, so ACR can be used as an alternative to 24-hour urinary protein quantitative detection of indicators for the early diagnosis of diabetic nephropathy.