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目的探讨血清C-反应蛋白(CRP)是否可以作为子痫前期及子痫的预测指标并与其发病的关系。方法对该院2015年1月-2016年12月收治的132例子痫前期及子痫患者(其中轻度63例,重度42例,子痫27例)及212例正常孕妇进行病例对照研究。结果首次产检时CRP水平差异没有统计学意义,随着孕周的增加,CRP水平升高。轻度子痫前期组、重度子痫前期组、子痫组患者血清CRP水平明显高于正常妊娠孕妇,差异具有统计学意义(P<0.01),且子痫组比重度子痫前期组、轻度子痫前期组明显升高,差异有统计学意义(P<0.05)。随着疾病严重程度的增加,分娩时CRP水平升高,各组之间差异具有统计学意义(F=26.153,P<0.05)。结论不同孕周的CRP水平不同,随着孕周的增加而增加;子痫前期及子痫患者分娩时C-反应蛋白显著升高;随着疾病严重程度的增加分娩时CRP水平升高。孕妇要严密监测CRP水平的变化,对CRP的升高及早进行干预,改善不良妊娠结局。
Objective To investigate whether serum C-reactive protein (CRP) can be used as a predictor of preeclampsia and eclampsia and its relationship with its pathogenesis. Methods 132 cases of preeclampsia and eclampsia in our hospital from January 2015 to December 2016 were retrospectively studied. Among them, 63 cases were mild, 42 cases were severe and 27 cases were eclampsia. Results There was no significant difference in CRP level between the first seizure and the second seizure. CRP levels increased with gestational age. The levels of serum CRP in mild preeclampsia group, severe preeclampsia group and eclampsia group were significantly higher than those in normal pregnant women (P <0.01). The levels of serum CRP in severe preeclampsia group and severe preeclampsia group were significantly lower than those in normal preeclampsia group Preeclampsia group was significantly higher, the difference was statistically significant (P <0.05). With the increase of disease severity, the level of CRP in labor increased, the difference between each group was statistically significant (F = 26.153, P <0.05). Conclusions CRP levels vary with gestational age and increase with gestational age. C-reactive protein is significantly increased at delivery in preeclampsia and eclampsia, and CRP increases with childbirth. Pregnant women should be closely monitored changes in CRP levels, the early intervention of elevated CRP to improve adverse pregnancy outcomes.