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含氮类药物测定苯丙胺中的左旋和右旋异构体比例的方法,是将苯丙胺与 N-三氟乙酰-左旋-脯氨酰氯反应生成衍生物,然后在1%Carbo-wax 20M 柱上于185°层析。方法能用于商品片剂和结晶盐,能检测右旋苯丙胺中少至1%的左旋苯丙胺。标准偏差<0.64%。长效片剂中甲基苯丙胺(Ⅰ)的测定,是将药片溶于氯仿,用碱使(Ⅰ)游离,加入内标物正
The method of determining the ratio of levorotary and dextrorotatory isomers of amphetamines using nitrogen-containing drugs is to react the amphetamine with N-trifluoroacetyl-L-prolyl chloride to give a derivative which is then purified on a 1% Carbo-wax 20M column 185 ° chromatography. The method can be applied to commercial tablets and crystalline salts and can detect as little as 1% of dextroamphetamine in dextroamphetamine. Standard deviation <0.64%. Long-acting tablets in the determination of methamphetamine (Ⅰ), the tablets are dissolved in chloroform, alkali (Ⅰ) free, add the internal standard positive