论文部分内容阅读
目的 探讨免疫抑制剂环孢霉素 A(CsA)对老龄大鼠慢性脑灌注不足脑损害的防护作用和可能机制。方法 30只老龄大鼠持久性双侧颈总动脉结扎 (2VO)，其中 12只接受 CsA胃灌治疗。脑组织学改变采用光镜和电镜观察。 CsA作用的研究为持久性 2VO 2月。结果 大鼠持久性 2VO诱导的慢性脑灌注不足造成了大脑多发性脑梗死，进行性皮层和海马神经元退变以及脑白质损害， CsA治疗后脑损害明显减轻。结论 免疫抑制剂 CsA可明显抑制大鼠慢性脑灌注不足脑损害。
Objective To investigate the protective effect and possible mechanism of immunosuppressant cyclosporine A (CsA) on brain damage in chronic cerebral hypoperfusion in aged rats. Methods Thirty elderly rats were subjected to permanent bilateral common carotid artery ligation (2VO), of which 12 received CsA gastric perfusion. Brain histological changes were observed by light and electron microscopy. The study of CsA action was persistent 2VO 2 months. Results Persistent 2VO-induced chronic cerebral hypoperfusion resulted in multiple cerebral infarction, degeneration of cortical and hippocampal neurons and white matter damage in rats. The brain damage after CsA treatment was significantly reduced. Conclusion The immunosuppressive agent CsA can significantly inhibit brain damage in rats with chronic cerebral hypoperfusion.